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The active substance is rapidly absorbed by perfusion, reaches the limiting level after two hours, the characteristics do not depend on food intake.
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methicatechol glucuronide.
There are a limited number of indications for the use of Cialis.
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erectile dysfunction (erectile dysfunction)
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Tadalafil does not affect visual acuity, intraocular pressure, electroretinogram, does not change the size of the pupil, does not dilate blood vessels. There was no effect of the drug on the quantitative and qualitative parameters of sperm in patients who took the drug for six months, compared with placebo.
94% of the dose combines with plasma proteins, metabolizes with the participation of the cytochrome isoenzyme with the formation of an inactive metabolite of They are indicated in the instructions:
; symptoms of lower urinary tract damage in patients suffering from benign prostatic hyperplasia with or without a decrease in potency.
If the patient exhibits frequent sexual activity (intercourse occurs more often than twice a week), he is prescribed 5 mg tablets daily, one at a time. If individual intolerance occurs, the dosage of Cialis is reduced to 2.5 mg. With rare sexual activity, the drug is taken right before intercourse at a dose of 20 mg. The maximum daily dose, according to the instructions, is 20 mg.
In a benign state of prostatic hyperplasia with or without erectile dysfunction, patients are prescribed to take the drug once a day, one tablet at the same time (regardless of the frequency of sexual activity, food intake). The duration of treatment is determined by the urologist. With moderate lesions of renal function, dose adjustment is not needed, with severe - daily use of the drug is contraindicated.
The instructions for use of Cialis states that the drug must be taken at least 15 minutes before the desired sexual activity in order for it to take effect. The working time of the medicinal product is 36 hours. During this period, the patient can carry out any number of attempts at sexual intercourse. Maximum of one tablet per day can be taken.
The medication is prescribed with extreme caution and, if absolutely necessary, for severe renal and hepatic insufficiency. Treatment of erectile dysfunction with Cialis should not be carried out in men with heart disease, in which sexual activity is contraindicated.
The estimated risk of complications during sexual activity develops with myocardial infarction, unstable angina pectoris, chronic heart failure, uncontrolled heartbeat disorders, arterial hypotension or hypertension, stroke less than six months ago. Cialis is used with caution when there is a predisposition to priapism (factors are multiple myeloma, sickle cell anemia, leukemia), with anatomical deformational pathologies of the penis.
